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Alveolar dead space 1ml per pound2/22/2024 The different gradients between ventilation and perfusion across the lung lead to a high V/ Q ratio (>1) in the nondependent regions and a low V/ Q ratio (<1) in the dependent regions (Fig. This higher rate of increase in perfusion from nondependent to dependent lung regions leads to imperfect V/ Q matching. Similarly, pulmonary perfusion is higher in dependent regions of the lung, but there is a greater change in perfusion across the lung when compared to ventilation. As discussed previously, regional differences exist within the lung, and ventilation is higher in dependent lung units. Under ideal circumstances, pulmonary perfusion ( Q) would perfectly match the differential ventilation ( V) of various lung units and create a ventilation to perfusion ratio ( V/ Q ratio) of 1. V/ Q matching is an important element in pulmonary gas exchange since only the gas that reaches the alveolar-capillary interface is available for exchange.
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